Introduction: Kawasaki disease is an acute vesiculitis that involves medium-sized vessels. The disease affects children and adolescents predominantly. Considering the importance of this disease and the prevalence of it in Bandar Abbas, the aim of this retrospective descriptive study was to compare the clinical and laboratory symptoms of Kawasaki patients admitted to Bandar Abbas Children Hospital during 2012-2015. Methods: The data was collected using a researcher-made checklist. The checklist had two parts; the first part was non-specialized information such as age, sex, season of illness, and the second part contained specialized information such as clinical and paraclinical manifestations. Results: The minimum age was two months and the maximum age was 144 months. The highest incidence was between 24-36 months in 7 cases (25%) and the lowest was between 12-24 months in 2 cases (7.1%). In terms of clinical manifestations, 22 cases (78.6%) of conjunctivitis, 23 cases (82.1%) of rash, 21 (75%) cases of lymphopoenitis, and 27 (96.4%) cases of oral cavity complication were observed. Increased ESR in 17 patients (60.7%), leukocytosis in 5 patients (17.9%), anemia in 9 patients (32.1%), thrombocytosis in 8 patients (28.6%), and thrombocytopenia in 2 patients (7.1%) were observed. Conclusion: Knowledge about the sign and symptoms and laboratory abnormalities in Kawasaki disease is important for early diagnosis and treatment of it.
Kawasaki disease, Fever, Anemia
1. Burgner D, Harnden A. Kawasaki disease: what is the epidemiology telling us about the etiology? International journal of infectious diseases. 2005;9(4):185-94.
2. Kawasaki T. Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children. Arerugi. 1967;16:178-222.
3. Yanagawa H, Nakamura Y, Ojima T, Yashiro M, Tanihara S, Oki I. Changes in epidemic patterns of Kawasaki disease in Japan. The Pediatric infectious disease journal. 1999;18(1):64-6.
4. Shiari R. Kawasaki Disease; A Review Article. Archives of Pediatric Infectious Diseases. 2014;2(1):154-9.
5. Burns JC, Shimizu C, Gonzalez E, Kulkarni H, Patel S, Shike H, et al. Genetic variations in the receptor-ligand pair CCR5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease. The Journal of infectious diseases. 2005;192(2):344-9.
6. Krensky AM, Berenberg W, Shanley K, Yunis EJ. HLA antigens in mucocutaneous lymph node syndrome in New England. Pediatrics. 1981;67(5):741-3.
7. Yeung RS. Kawasaki disease: update on pathogenesis. Current opinion in rheumatology. 2010;22(5):551-60.
8. Okano M, Thiele GM, Sakiyama Y, Matsumoto S, Purtilo DT. Adenovirus infection in patients with Kawasaki disease. Journal of medical virology. 1990;32(1):53-7.
9. Nigro G, Krzysztofiak A, Porcaro M, Mango T, Zerbini M, Gentilomi G, et al. Active or recent parvovirus B19 infection in children with Kawasaki disease. The Lancet. 1994;343(8908):1260-1.
10. Leung DY, Kotzin B, Meissner H, Fulton R, Murray D, Schlievert PM. Toxic shock syndrome toxin-secreting Staphylococcus aureus in Kawasaki syndrome. The Lancet. 1993;342(8884):1385-8.
11. Muso E, Fujiwara H, Yoshida H, Hosokawa R, Yashiro M, Hongo Y, et al. Epstein-Barr virus genome-positive tubulointerstitial nephritis associated with Kawasaki disease-like coronary aneurysms. Clinical nephrology. 1993;40(1):7-15.
12. Normann E, Nääs J, Gnarpe J, Bäckman H, Gnarpe H. Demonstration of Chlamydia pneumoniae in cardiovascular tissues from children with Kawasaki disease. The Pediatric infectious disease journal. 1999;18(1):72-3.
13. Leen C, Ling S. Mycoplasma infection and Kawasaki disease. Archives of Disease in Childhood. 1996;75(3):266.
14. Fujita Y, Nakamura Y, Sakata K, Hara N, Kobayashi M, Nagai M, et al. Kawasaki disease in families. Pediatrics. 1989;84(4):666-9.
15. Uehara R, Yashiro M, Nakamura Y, Yanagawa H. Kawasaki disease in parents and children. Acta Paediatrica. 2003;92(6):694-7.
16. Barron KS. Kawasaki disease in children. Current opinion in rheumatology. 1998;10(1):29-37.
17. Harnden A, Alves B, Sheikh A. Rising incidence of Kawasaki disease in England: analysis of hospital admission data. Bmj. 2002;324(7351):1424-5.
18. Newburger JW, Takahashi M, Burns JC, Beiser AS, Chung KJ, Duffy CE, et al. The treatment of Kawasaki syndrome with intravenous gamma globulin. New England Journal of Medicine. 1986;315(6):341-7.
19. Park YW, Kim CH, Park IS, Ma JS, Lee SB, Kim CH, et al. Epidemiologic study of Kawasaki disease in Korea, 1994-1996: comparison of previous study in 1991-1993. Journal of the Korean Pediatric Society. 1999;42(9):1255-60.
20. Dajani AS, Taubert KA, Gerber MA, Shulman ST, Ferrieri P, Freed M, et al. Diagnosis and therapy of Kawasaki disease in children. Circulation. 1993;87(5):1776-80.
21. Furusho K, Nakano H, Shinomiya K, Tamura T, Manabe Y, Kawarano M, et al. High-dose intravenous gammaglobulin for Kawasaki disease. The Lancet. 1984;324(8411):1055-8.
22. Rowley AH. Incomplete (atypical) Kawasaki disease. The Pediatric infectious disease journal. 2002;21(6):563-5.
23. Salo E. Kawasaki disease in Finland in 1982–1992. Scandinavian journal of infectious diseases. 1993;25(4):497-502.
24. McCrindle BW, O’Shea S, Lew B, Masood S, Bock D, Lai LS, et al. Abstract O. 06: Epidemiology of Kawasaki Disease in Canada (2004-2011). Am Heart Assoc; 2015.
25. Nakamura Y, Yashiro M, Uehara R, Sadakane A, Tsuboi S, Aoyama Y, et al. Epidemiologic features of Kawasaki disease in Japan: results of the 2009–2010 nationwide survey. Journal of Epidemiology. 2012;22(3):216-21.
26. Manlhiot C, Christie E, McCrindle BW, Rosenberg H, Chahal N, Yeung RS. Complete and incomplete Kawasaki disease: two sides of the same coin. European journal of pediatrics. 2012;171(4):657-62.
27. Bratincsak A, Reddy VD, Purohit PJ, Tremoulet AH, Molkara DP, Frazer JR, et al. Coronary artery dilation in acute Kawasaki disease and acute illnesses associated with Fever. The Pediatric infectious disease journal. 2012;31(9):924-6.
28. ElAdawy M, Dominguez SR, Anderson MS, Glodé MP. Abnormal liver panel in acute Kawasaki disease. The Pediatric infectious disease journal. 2011;30(2):141.
29. Beken B, Ünal Ş, Çetin M, Gümrük F. The relationship between hematological findings and coronary artery aneurysm in kawasaki disease. Turkish Journal of Hematology. 2014;31(2):199.
30. Kuo HC, Liang CD, Wang CL, Yu HR, Hwang KP, Yang KD. Serum albumin level predicts initial intravenous immunoglobulin treatment failure in Kawasaki disease. Acta Paediatrica. 2010;99(10):1578-83.